Short Communication: Genetic Ablation of L-Type Ca ²⁺ Channels Abolishes Depolarization-Induced Ca ²⁺ Release in Arterial Smooth Muscle

Abstract

These data suggest that Ca(v)1.2 channels are indeed voltage sensors coupled to the metabolic cascade, leading to SR Ca(2+) release. These findings support a novel, ion-independent, functional role of L-type Ca(2+) channels linked to intracellular signaling pathways in vascular myocytes.