Targeting RNAs with Tobramycin Analogues

Abstract

A library of 4,6-linked analogues of the drug tobramycin with various mono- or diaminosugars attached to the 6-position of the two-ring core has been prepared (see scheme; Bn=benzyl, Tol=p-tolyl). The compounds were screened against different disease-related RNAs, and several of the synthetic analogues showed a high affinity and selectivity toward certain RNA sequences.