A Common Genetic Variant in the 3′-UTR of Vacuolar H ⁺ -ATPase <i>ATP6V0A1</i> Creates a Micro-RNA Motif to Alter Chromogranin A Processing and Hypertension Risk

Abstract

The results suggest a series of events whereby ATP6V0A1 3'-UTR variant T+3246C functioned: ATP6V0A1 expression probably was affected through differential micro-RNA effects, altering vacuolar pH and consequently CHGA processing and exocytotic secretion.