1c:I[776865,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"Grid"] 1d:I[617291,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"GridCol"] 1e:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1f:T406,During the past decade, knowledge of the clinical course of coronary artery thrombosis and the pathologic changes associated with it has been increased rapidly. Nevertheless, the actual events which precipitate an attack remain a matter of speculation. Characteristically, an attack of angina pectoris follows physical exertion or emotional stress, and without critical analysis the same factors have been considered responsible for inducing coronary artery thrombosis. Fitzhugh and Hamilton¹and others²expressed the belief that coronary thrombosis follows unusual exertion. Riesman and Harris³and Wolff and White⁴concurred with them but pointed out that an attack often occurs while the patient is at rest or even in bed. Other authors⁵found no definite relationship between physical stress and coronary thrombosis. Luten⁶went so far as to state that the attack invariably occurs in the absence of effort. Similarly, the importance of occupation and social status20:T49f,In an attempt to study effects of cold on blood pressure and the renin-angiotensin-aldosterone system, 34 healthy young subjects with or without a family history of essential hypertension were exposed to moderate cold (4 degrees C for 1 h) or severe cold (immersion of the hands to 0 degrees C for 10 min). Moderate cold elevated blood pressure, aldosterone, cortisol and noradrenaline when the subjects wore summer clothing but not when the subjects wore winter clothing. Regardless of the clothing worn, skin blood flow and plasma renin activity decreased significantly in response to moderate cold but angiotensin II decreased insignificantly. Severe cold elevated blood pressure, cortisol, aldosterone and noradrenaline. Administration of dexamethasone significantly depressed an increase of aldosterone and cortisol in response to cold but failed to effect an elevation of blood pressure and noradrenaline. Plasma renin activity and angiotensin II concentration were not affected at all during and after cold exposure. It is suggested that, among the various hormones studied, noradrenaline is the only hormone responsible for an elevation of blood pressure in response to cold.

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