Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges

Abstract

Oligomers containing the peptide sequence cysteine-any-cysteine (CXC) were attached, at specific locations, to a linear chain of polystyrene. The polymer-bound peptide motifs were then oxidized under dilute conditions to afford a complex bio-hybrid bi-cyclic topology via intramolecular twin disulfide bridge formation.