Whole-Exome Sequencing of Muscle-Invasive Bladder Cancer Identifies Recurrent Mutations of <i>UNC5C</i> and Prognostic Importance of DNA Repair Gene Mutations on Survival

Abstract

Better prognostic outcomes of individuals carrying somatic mutations in DNA repair genes suggest these mutations as favorable prognostic events in muscle-invasive bladder cancer. Additional mechanistic investigation into the previously undiscovered role of UNC5C in bladder cancer is warranted.