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The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition

Channel FunctionMolecular NeuroscienceVoltage SensorNeurophysiologyPhysiologyNeuropeptide ReceptorIon ChannelsNeuropharmacologyCacna1a ResultsNeuroscienceNeurotransmissionNeurologyNervous SystemMolecular NeurobiologyMedicineSynaptic SignalingSocial SciencesNeurogenetics