Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice

Abstract

EV from MCT-injured mice contribute to the development of MCT-induced pulmonary hypertension. This effect may be mediated directly by EV on the pulmonary vasculature or by differentiation of bone marrow cells to endothelial progenitor cells that induce pulmonary vascular remodelling.