Studies on Organophosphorus Compounds 92: A Facile Synthesis of 1-Substituted 5-Trifluoromethylimidazole-4-phosphonates

Abstract

Base-induced cycloaddition of diethyl isocyanomethylphosphonate to trifluoroacetimidoyl chlorides gives 1-substituted diethyl 5-trifluoromethylimidazole-4-phosphonates with high regioselectivity.