Immunomodulatory and In vivo Antiplasmodial Activities of Propolis Extracts

Abstract

Abstract: The purpose of this research was to evaluate the immunomodulator and antiplasmodial activities of Indonesian propolis extracts. This research utilized not only hypersensitivity reaction which measures the humoral immunity by SRBC-immunized mice but also the activity and capacity of peritoneum macrophage phagocytosis in Plasmodium berghei-infected mice. The parasitaemia number was calculated using blood smear method every day for 4 day after the mice had been infected P. berghei to identify the antiplasmodial activity. The research results reveal that propolis hydroalcoholic solution (PHS) has a strong immunomodulatory activity but weak antiplasmodial activity. Key words: Propolis Immunomodulator Antiplasmodial INTRODUCTION mechanism of humoral immunity in eliminating Propolis (bee glue) is a dark-coloured resinous antimalarial antibody is strongly suspected to play substance collected by bees from poplar buds and other important role in immunity. The aim of this study was to plants and used to seal their hives [1]. More than 180 evaluate the antiplasmodial and immunomodulatory propolis constituents have been identified by gas activities of propolis.