Molecular Characterization of the <i>vanE</i> Gene Cluster in Vancomycin-Resistant <i>Enterococcus faecalis</i> N00-410 Isolated in Canada

David A. Boyd, Thiago Cabral, Paul Van Caeseele, Jason Wylie, M. R. Mulvey

Antimicrobial Agents and Chemotherapy · 2002 · 32 citations · 14 references

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Abstract

The vanE operon was characterized from Enterococcus faecalis N00-410 (MIC of vancomycin = 24 microg/ml). The organization of the vanE operon was identical to that of the vanC1 operon from Enterococcus gallinarum, with protein identities ranging from 46 to 63%. An open reading frame located downstream of the vanE operon showed significant homology to a number of integrase genes, all of which are located downstream of the chromosomal GMP synthase gene guaA.

References

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