MedicineCardiologySurgeryHemostasisTissue EngineeringVascular SurgeryPlatelet FunctionPlatelet PhysiologyPlatelet TransfusionArterial HemostasisAutologous Platelet ConcentratesBleeding Risk ReductionHemostatic BiomaterialsMicroscopic MorphologyPlatelet-rich Plasma InjectionPorosity
Severe and even fatal hemorrhage may be caused by bleeding through the interstices of a fabric graft. Improved fabrication of grafts with appropriate porosity for the conditions encountered has provided better hemostasis. Yet in some situations, bleeding through the fabric still presents a problem. A method of preclotting with autologous platelet rich plasma (PRP) and autoclaving is described. Gross and microscopic studies along with clinical applications confirm the effectiveness of the technique.
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Graft Hemostasis: An Alternative to Preclotting
Morrison C. Bethea, K Reemtsma · The Annals of Thoracic Surgery · 1979 · 35 citations · Full text