Analysis of Drug Release Kinetics from Degradable Polymeric Devices

Abstract

Drug release kinetics from a degradable polymer undergoing surface erosion have been analysed by mathematical modelling and stimulations. This approach considers drug particles homogeneously dispersed in the matrix, and cases of both a single polymer matrix and a matrix surrounded by a membrane are considered. The influence of different polymer, drug, and membrane parameters on long-term performance has been simulated and provides a theoretical basis for the design of degradable drug delivery devices.