Cross-elicitation responses to 2-methoxymethyl-<i>p</i>-phenylenediamine under hair dye use conditions in<i>p</i>-phenylenediamine-allergic individuals

Abstract

Under simulated hair dye use conditions, a significantly lower degree of cross-elicitation to ME-PPD (30%) was observed than previously reported for PPD (32 of 38, 84%). Additionally, a decreased cross-elicitation strength was observed across all three patch test grades, likely reflecting the reduced skin-sensitization properties of ME-PPD. Consequently, careful dermatological evaluation is required to assess cross-reactivity to ME-PPD in patients allergic to hair dyes.