HIV Coinfection Impairs CD28‐Mediated Costimulation of Hepatitis C Virus–Specific CD8 Cells

Abstract

These results indicate that, during HCV/HIV coinfection, memory-effector CD8 cells have reduced responsiveness to CD28 costimulation. This appears to reflect a global effect that HIV has on the activation or differentiation state of CD8 cells that are responsive to other microbial pathogens. This functional defect has implications for the pathogenesis of HCV/HIV coinfection.