Concepedia

Squamous cell carcinoma arising in a tall cell papillary carcinoma of the thyroid

Judit Sutak, J S Armstrong, Jennifer Rusby

Journal of Clinical Pathology · 2005 · 28 citations · 6 references

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Concepts

Abstract

Transformation of differentiated thyroid cancer into poorly differentiated carcinoma is rare. This report describes a case in which preoperative fine needle aspiration suggested a squamous cell carcinoma whereas needle core biopsy favoured an undifferentiated carcinoma of probable thyroid origin. Histology of the subsequent total thyroidectomy specimen revealed a biphasic tumour comprising areas of tall cell papillary carcinoma merging with moderately to poorly differentiated squamous cell carcinoma. The immunohistochemical findings are discussed in detail.

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