Concepedia

Evaluation of Hepatitis C Virus Core Antigen Assays in Detecting Recombinant Viral Antigens of Various Genotypes

Mohsan Saeed, Ryosuke Suzuki, Madoka Kondo, Hideki Aizaki, Takanobu Kato, Toshiaki Mizuochi, Takaji Wakita, Haruo Watanabe, Tetsuro Suzuki

Journal of Clinical Microbiology · 2009 · 11 citations · 14 references

DOIFull text

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Concepts

Abstract

A single substitution within the hepatitis C virus core antigen sequence, A48T, which is observed in approximately 30% of individuals infected with genotype 2a virus, reduces the sensitivity of a commonly used chemiluminescence enzyme immunoassay. Quantitation of the antigen is improved by using a distinct anticore antibody with a different epitope.

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