Correlation of Tumor Markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 With Survival and Metastasis in Laryngeal Squamous Cell Carcinoma

Abstract

The present study suggests that a loss of cell proliferation control implied by overexpression of p53 and loss of cell adhesion implied by decreased expression of CD44 may be determinants of survival in patients with carcinoma of the larynx. The tumor markers bcl-2 and Ki-67 were not prognostic discriminators in this limited series. This study also indicates that the stem cell marker CD34 is rarely expressed by laryngeal carcinoma cells.