Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence <i>In situ</i> Hybridization–Based Case-Control Study

Abstract

We have developed a sensitive and quantitative antigen-independent FISH-based test for detecting CACs in peripheral blood of patients with NSCLC, which showed a significant correlation with the presence of cancer. If this pilot study can be validated in a larger study, CACs may have a role in the management of patients with NSCLC.