The incorporation of the concept of minimum RBE ( <i>RBE</i> _min ) into the linear-quadratic model and the potential for improved radiobiological analysis of high-LET treatments

Abstract

If the production of sublethal damage is considered independent of LET, there will be a risk that non-corrected evaluation of RBE will lead to an over- or under-estimate of RBE at low doses per fractions (the clinically relevant region).