The Journal of Clinical Endocrinology & Metabolism · 1977 · 13 citations · 11 references
PharmacyPharmacologyPharmacotherapyEndocrine PharmacotherapyLactationLactation PhysiologyEndocrine PharmacologyHormone ReleaseHormone SecretionLactation PharmacotherapyMilk SecretionProlactin PhysiologyHypothalamic Regulation Of ProlactinHypothalamic-pituitary-prolactin AxisMechanical Breast PumpingProlactin MetabolismProlactin PharmacologyProlactin Release MechanismsProlactin Secretion Regulation
Ten women were studied during the first post-partum week. Mechanical breast emptying with a breast pump for 30 min induced a marked increase in plasma prolactin (PRL) reaching a maximum 30 min after the beginning of stimulation. In all patients oral administration of the antiserotonin agent metergoline, 8 mg daily for two days, completely blocked any PRL secretion induced by breast stimulation. These results confirm the inhibitory effect of metergoline on PRL release.
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