Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein

Abstract

Wide expression of HHLA2 in human malignancies, together with its association with poor prognostic factors and its T-cell coinhibitory capability, suggests that the HHLA2 pathway represents a novel immunosuppressive mechanism within the tumor microenvironment and an attractive target for human cancer therapy.