Non-invasive radioiodine imaging for accurate quantitation of NIS reporter gene expression in transplanted hearts☆☆☆

Abstract

These data demonstrate that hNIS is an excellent reporter gene for the transplanted heart. The expression level of hNIS can be accurately and non-invasively monitored by serial radioisotopic SPECT imaging. High concordance has been demonstrated between imaging and soluble marker peptides at the maximum transgene expression on POD 5.