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Publication | Open Access

PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension

DOIFull Paper Access

195

Citations

48

References

2013

Year

John Ryan, Glenn Marsboom, Yong-Hu Fang, Péter T. Tóth, Erik Morrow, Nancy Luo, Lin Piao, Zhigang Hong, Kyle Ericson, Hannah J. Zhang,
American Journal of Respiratory and Critical Care Medicine

Abstract

Decreased expression of MFN2 and PGC1α contribute to mitochondrial fragmentation and a proliferation-apoptosis imbalance in human and experimental PAH. Augmenting MFN2 has therapeutic benefit in human and experimental PAH.

References

YearCitations

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