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A Structural and Functional Model of Galactose Oxidase: Control of the One-Electron Oxidized Active Form through Two Differentiated Phenolic Arms in a Tripodal Ligand
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2002
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Bioorganic ChemistryBiochemistryNatural SciencesBiocatalysisGalactose OxidaseGlycobiologyEnzyme CatalysisMolecular BiologyAxial Phenol GroupStructure-function Enzyme KineticsRedox ChemistryFunctional ModelChemical BiologyMedicineRedox BiologyCarbohydrate-protein InteractionEnzyme ChemistryDifferentiated Phenolic Arms
The axial phenol group is protonated and the equatorial phenoxyl group antiferromagnetically coupled to the cupric center in the complex [CuII(LH)(OAc)].+ (see picture), which can be considered as both a structural and functional model of galactose oxidase. This complex reproduces the features of the enzyme chemistry. The phenoxyl radical position (equatorial versus axial) is dictated by protonation.