The Impact of Clone Size on the Prognostic Value of Chromosome Aberrations by Fluorescence <i>In Situ</i> Hybridization in Multiple Myeloma

Abstract

Our study indicated that the impact of clone size on prognostic value varies between specific genetic abnormalities. Prognostic value was observed for even a subgroup of plasma cells harboring the cytogenetic aberration of 13q deletion and 1q21 gains; however, 17p deletion displayed the most powerful cutoff for predicting survival only if the predominant clones harbored the abnormality.