Detection of Malignant Hepatic Lesions Before Orthotopic Liver Transplantation: Accuracy of Ferumoxides-Enhanced MR Imaging

Abstract

Ferumoxides-enhanced gradient-echo sequences improved the diagnostic accuracy and the sensitivity for detecting malignant hepatic lesions in patients with end-stage cirrhosis of the liver. However, the specificity was not improved even after the administration of ferumoxides because of the false-positive lesions that were mainly the result of fibrotic changes.