Self‐Replicating Amphiphilic β‐Sheet Peptides

Abstract

Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu-(Phe-Glu)n molecules. The peptides form soluble one-dimensional β-sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self-replication. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.