Proinflammatory Effects of Bare and PEGylated ORMOSIL-, PLGA- and SUV-NPs on Monocytes and PMNs and Their Modulation by F-MLP

Abstract

ORMOSIL-NPs are preferentially captured by circulating monocytes but stimulate both monocytes and PMNs per se or by sensitizing them to another agonist (f-MLP). PEG-coating confers stealth effects but does not completely eliminate leukocyte activation. Safe nanomedical applications require the evaluation of both intrinsic and cooperative proinflammatory potential of NPs.