Enantioselective Total Syntheses of Three Cladiellins (Eunicellins): A General Approach to the Entire Family of Natural Products

Abstract

Stereoselective rearrangement of a free or metal-bound oxonium ylide, generated by rhodium-catalyzed intramolecular cyclization of the diazo ketone 1, afforded E-configured O-bridged bicyclic ether (E)-2, which was efficiently transformed into (−)-cladiella-6,11-dien-3-ol. TBS=tert-butyldimethylsilyl. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.