Improved Molecular Detection of Dengue Virus Serotype 1 Variants

Jean‐Marc Reynes, Sivuth Ong, Channa Mey, Chantha Ngan, Stefan Hoyer, Amadou A. Sall

Journal of Clinical Microbiology · 2003 · 43 citations · 11 references

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Abstract

The dengue virus molecular typing method described by Lanciotti and coworkers (R. S. Lanciotti, C. H. Calisher, D. J. Gubler, G. J. Chang, and A. Vance-Vorndam, J. Clin. Microbiol. 30:545-551, 1992) is used worldwide for diagnosis and surveillance. However, it failed to detect DENV-1 variants in Cambodia due to a point mutation. We describe an improvement of the method that allows the detection of additional DENV-1 strains, including potential variants.

References

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