Concepedia

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Jun Cui, Yinyin Li, Liang Zhu, Dan Liu, Zhou Songyang, Helen Y. Wang, Rong‐Fu Wang

Nature Immunology · 2012 · 298 citations · 25 references

DOI

Concepts

References

25

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm et al. · Nature · 2009 · 4.2K citations · Full text

, , +13

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, Daniel C. Rowe et al. · Nature Immunology · 2003 · 2.7K citations

, , +6

IFI16 is an innate immune sensor for intracellular DNA

Leonie Unterholzner, Sinéad E. Keating, Marcin Baran et al. · Nature Immunology · 2010 · 1.6K citations · Full text

, , +14

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

Yu‐Hsin Chiu, John B. MacMillan, Zhijian J. Chen · Cell · 2009 · 1.2K citations · Full text

, , +12

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

Kenya Honda, Yusuke Ohba, Hideyuki Yanai et al. · Nature · 2005 · 891 citations

, , +16