Rapid brain penetration of interleukin‐1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

Abstract

These data are the first to show that a potential treatment for stroke, IL-1RA, rapidly reaches salvageable brain tissue via an administration route that is clinically relevant. This allows confidence that IL-1RA, as a candidate for further clinical development, is able to confer its protective actions both peripherally and centrally.