Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against <i>Klebsiella pneumoniae</i> , <i>Enterobacter cloacae</i> , and <i>Acinetobacter baumannii</i> Clinical Isolates

Abstract

The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.