Concepedia

Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes

Hirotoshi Ishiwatari, Yasushi Sato, Kazuyuki Murase, Akihiro Yoneda, Ryosuke Fujita, Hiroki Nishita, Naoko Birukawa, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi,

Gut · 2012 · 70 citations · 24 references

DOIFull text

Open access

Abstract

These data suggest the therapeutic potential of the present approach for reversing pancreatic fibrosis.

References

24

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

John P. Iredale, R. Christopher Benyon, J. Pickering et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Identification, culture, and characterization of pancreatic stellate cells in rats and humans

Max G. Bachem, Erik Schneider, Hans Groß et al. · Gastroenterology · 1998 · 1K citations · Full text

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Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture

Minoti V. Apte, Paul Haber, Tanya Applegate et al. · Gut · 1998 · 905 citations · Full text

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

Yasushi Sato, Kazuyuki Murase, Junji Kato et al. · Nature Biotechnology · 2008 · 589 citations

, , +13

Extracellular Matrix Binding Properties of Recombinant Fibronectin Type II-like Modules of Human 72-kDa Gelatinase/Type IV Collagenase

Bjorn Steffensen, U. Margaretha Wallon, Christopher M. Overall · Journal of Biological Chemistry · 1995 · 223 citations · Full text