Mild Cognitive Impairment: Cerebrospinal Fluid Tau Biomarker Pathologic Levels and Longitudinal Changes in White Matter Integrity

Abstract

Reduction in WM integrity was greater in patients with MCI who had the most intense neuronal degeneration as indexed by using CSF total tau, suggesting that these patients might represent a subgroup of MCI with more intense WM degeneration who are possibly at greater risk of developing Alzheimer disease.