N‐Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones

Abstract

The dynamic kinetic resolution of 6-hydroxypyranones with enals or alkynals through an asymmetric redox esterification is catalyzed by a chiral N-heterocyclic carbene. The resulting esters are obtained in good to high yields and with high levels of enantio- and diastereocontrol. The reaction products are further derivatized to obtain functionalized sugar derivatives and natural products.