High Doses of Vitamin C Reverse <i>Escherichia coli</i> Endotoxin–Induced Hyporeactivity to Acetylcholine in the Human Forearm

Abstract

Our data demonstrate that impaired endothelial vasodilation caused by E coli endotoxemia can be counteracted by high doses of antioxidants in vivo. Oxidative stress may play an important role in the pathogenesis of endothelial dysfunction during inflammation.