Concepedia

Cholesteryl Ester Transfer Protein Decreases High-Density Lipoprotein and Severely Aggravates Atherosclerosis in <i>APOE*3-Leiden</i> Mice

Marit Westerterp, Caroline C. van der Hoogt, Willeke de Haan, Erik H. Offerman, Geesje M. Dallinga‐Thie, J. Wouter Jukema, Louis M. Havekes, Patrick C.N. Rensen

Arteriosclerosis Thrombosis and Vascular Biology · 2006 · 228 citations · 40 references

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Abstract

CETP expression in E3L mice shifts the distribution of cholesterol from HDL to VLDL/LDL, reduces plasma-mediated SR-BI-dependent cholesterol efflux, and represents a clear pro-atherogenic factor in E3L mice. We anticipate that the CETP.E3L mouse will be a valuable model for the preclinical evaluation of HDL-raising interventions on atherosclerosis development.

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