Concepedia

Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis

Paula Cunnea, Aoife Ní Mháille, Stephen McQuaid, Michael Farrell, Jill McMahon, Una FitzGerald

Multiple Sclerosis Journal · 2011 · 85 citations · 23 references

DOI

Abstract

Our results, showing detection of elevated expression of ER stress molecules in lesional tissue, offer compelling evidence for further investigation of the ER stress signalling pathway as a potential therapeutic target for the treatment of MS.

References

23

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

Claudia F. Lucchinetti, Wolfgang Br�ck, Joseph E. Parisi et al. · Annals of Neurology · 2000 · 3.3K citations

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Martin Schröder, Randal J. Kaufman · Annual Review of Biochemistry · 2005 · 3K citations

Cortical demyelination and diffuse white matter injury in multiple sclerosis

Alexandra Kutzelnigg, Claudia F. Lucchinetti, Christine Stadelmann et al. · Brain · 2005 · 1.8K citations

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Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression

Ping Hu, Han Zhang, Anthony D. Couvillon et al. · Molecular and Cellular Biology · 2006 · 737 citations · Full text

Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

Jing Deng, Phoebe D. Lu, Yuhong Zhang et al. · Molecular and Cellular Biology · 2004 · 629 citations · Full text