Small · 2013 · 123 citations · 29 references
Life SciencesBioengineeringBiologyAssisted Reproductive TechnologiesBiomemsReproductive BiologyMicrofluidicsSperm BiologySperm FunctionExhaustion ModelingMicrofluidic Channel NetworksMicrofluidic Sperm SortingSperm Motility DynamicsTime-to-exhaustion Tests
Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte
Gianpiero D. Palermo · The Lancet · 1992 · 3.6K citations
Medicine, Gynecology, Obstetrics +12
Mechanics of Motor Proteins and the Cytoskeleton
Jonathon Howard, RL Clark · Applied Mechanics Reviews · 2002 · 2.9K citations
Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
Sijia Lü, Chenghang Zong, Wei Fan et al. · Science · 2012 · 310 citations · Full text