Lymphomatous Optic Neuritis

Abstract

The relationship of lymphomatous disease to optic neuritis may be obscured by the wide separation in time of the ocular and systemic manifestations. This variation is found in two patients recently studied here: the first with blinding, bilateral neuritis occurring 15 years prior to diagnosis of Hodgkin's disease; the second with transient, unilateral, retrobulbar neuritis five years after detection of lymphosarcoma. <h3>Report of Cases</h3><h3>Case 1.</h3> —This was a 30-year-old white male whose present disorder began at age 11 with a rapid, bilateral loss of vision following an acute upper respiratory infection. Studies at another center, at that time (1941) included neurological examination and ventriculogram and were negative. Cervical lymphadenopathy was prominent, and a biopsy was interpreted as a reactive hyperplasia. Fundus examination showed neuroretinitis with vision OD, light perception; OS, 10/200. There was a slight blurring of the disc margin with loss of cup, some glial tissue along the