Attenuation of NF-?B signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes

Abstract

Neonatal and adult cardiomyocytes are resistant to the expression of pro-inflammatory genes due to impairment in the activation of IkappaB kinase, a process that might contribute to preventing rapid organ dysfunction in the course of various inflammatory pathologies, such as septic shock and myocarditis.