A Pilot Study of Human Interferon Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes

Abstract

The efficacy of this gene therapy was generally insufficient; however, some immunological responses were recognized in one patient. No adverse events were observed. HuIFNbeta gene therapy could be an attractive strategy for treatment of a variety of malignancies, including melanoma, though some modifications should be required.