Topical Prostaglandin F2α Treatment Reduces Collagen Types I, III, and IV in the Monkey Uveoscleral Outflow Pathway

Abstract

The cellular mechanism by which certain prostaglandins lower intraocular pressure is not known. The present study provides immunohistochemical data demonstrating that intraocular pressure reduction that occurs with topical prostaglandin F2alpha is associated with a reduction of collagens within the uveoscleral outflow pathway.