Exposure set-ups for in vivo experiments using radial waveguides

Abstract

Radial waveguide set-ups are introduced as exposure devices for long-term experiments with large numbers of non-restrained animals exposed simultaneously. Methods are presented to ensure well-defined exposure conditions even for potentially overmoded waveguides and for the exposure of large groups of animals per cage. The proposed methods are applied for a four-generation study being performed on up to 2500 mice exposed to a generic UMTS test signal at prescribed averaged whole body specific absorption rates (SARs). The variation of the whole body SAR due to the movement of the mice inside the cage is calculated by using the finite-difference time-domain method and detailed animal models for selected configurations of the mice inside the cage for all stages of the study.