Intracranial Perineural Extension of Invasive Mycosis: A Novel Mechanism of Disease Propagation by<i>Aspergillus fumigatus</i>

Abstract

We describe an immunocompetent woman who had refractory, invasive sphenoid sinus Aspergillus fumigatus infection for which there was radiologic evidence of intracranial perineural spread. The patient responded to a combination of antifungal and adjuvant recombinant cytokine therapy.