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Preparation of 1,2-benzisoxazole 2-oxides
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1986
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Experimental SynthesisEngineeringHeterocyclic1,2-Benzisoxazole 2-OxidesOxidative CyclisationO-acylphenol OximesOrganic ChemistryCatalysisChemistryHeterocycle ChemistrySynthesis MethodPharmacologySynthetic Chemistry
1,2-Benzisoxazole 2-oxides are prepared by the oxidative cyclisation of o-acylphenol oximes, using either lead(IV) acetate or sodium hypochlorite. The scope and limitations of the reaction are discussed.