Spherical Bioactive Glass with Enhanced Rates of Hydroxyapatite Deposition and Hemostatic Activity

Abstract

High-surface-area mesoporous bioactive glass materials have been developed, which demonstrate accelerated deposition rates of hydroxyapatite when immersed in simulated body fluids. Also, a novel blood-clotting application for bioactive glass materials, composed of microspheres (see TEM image), has been designed. Both bone growth and blood clotting are surface dependent hence the effect of changing the shape of the glass particles on the in vitro deposition rate and hemostatic efficacy has been investigated.