Copper‐Catalyzed Alkylation of Sulfonamides with Alcohols

Abstract

Water is the only by-product in an efficient and atom-economical Cu(OAc)2-catalyzed coupling of alcohols with sulfonamides (see proposed mechanism; Ts= p-toluenesulfonyl). It was discovered that bissulfonylated amidines formed as intermediates when the transhydrogenative CN bond-forming reaction is carried out in air act as novel ligands to stabilize the catalyst. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.